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Description
This module is about tissue repair processes, tissue regeneration and how cells, organs, and the body are organised in aiming to correct diseases. But also how, when the tissue repair process is dysregulated and chronic it becomes a major burden for the proper function of the organ and body.
In this module you will be firstly introduced to the concept of normal tissue repair and those molecular and cellular mechanisms that are important in tissue repair and regeneration. These processes will be discussed in normal human adult tissues and organs such as skin, liver, pancreas, kidney, heart and lung. Secondly, you will explore the various aspects of acute wound healing, as well as the principles of chronic wound healing and where things are going wrong, thus leading to diseases in the different organs. This will be further discussed with experimental research approaches that can be used to study these diseases. Further, you will gain knowledge in the complexity of these multi-cellular processes and multi-organ aspects of tissue regeneration in humans after injury and in disease, and their possible treatment options/mechanisms will be debated. As well as lectures you will have workshops/tutorials to further go into detail and to study how to read/write scientific papers.
Lecture topics:
- Human skin wound, tissue repair and regeneration
- The molecular mechanisms behind pancreatitis and cancer
- Liver fibrosis and inflammation, repair and regeneration, and what is the role of the myofibroblasts
- Primary and secondary liver cancer which are the overlapping mechanisms with liver regeneration
- Acute liver failure: TLR4 function in inflammation, repair and regeneration
- Regenerative Medicine and bio tissue engineering : 3D Platforms
- Obesity 鈥� liver 鈥� Cancer: where tissue repair goes wrong
- Inflammatory Bowel Disease: where tissue regeneration goes wrong
- Pulmonary diseases: from aetiology, shared pathogenic mechanisms and therapies/regeneration
- Regenerative Therapies for Cardiovascular Disease
- Kidney disease and regeneration
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 8th April 2024.
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